TAK-243 preferentially bound to UBA1 more than the connected E1 enzymes UBA2, UBA3, and UBA6 in intact AML cells. Inhibition of UBA1 with TAK-243 diminished levels of ubiquitylated proteins, elevated markers of proteotoxic stress and DNA problems pressure. In vivo, TAK-243 lowered leukemic load and focused leukemic stem cells with out proof of toxi
The Isorhamnetin-3-O-glucoside Diaries
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